EC	2.1.1.62
Accepted name:	mRNA (2′-O-methyladenosine-N6-)-methyltransferase
Reaction:	S-adenosyl-L-methionine + a 5-(N7-methyl 5-triphosphoguanosine)-2′-O-methyladenosine-[mRNA] = S-adenosyl-L-homocysteine + a 5-(N7-methyl 5-triphosphoguanosine)-N6,2′-O-dimethyladenosine-[mRNA]
Glossary:	a 5-(N7-methyl 5-triphosphoguanosine)-2′-O-methyladenosine-[mRNA] = m7G(5′)pppAm-[mRNA] a 5-(N7-methyl 5-triphosphoguanosine)-N6,2′-O-dimethyladenosine-[mRNA] = m7G(5′)pppm6Am-[mRNA]
Other name(s):	messenger ribonucleate 2′-O-methyladenosine NG-methyltransferase; S-adenosyl-L-methionine:mRNA (2′-O-methyladenosine-6-N-)-methyltransferase
Systematic name:	S-adenosyl-L-methionine:mRNA (2′-O-methyladenosine-N6-)-methyltransferase
References:	1.  Keith, J.M., Ensinger, M.J. and Moss, B. HeLa cell RNA (2′-O-methyladenosine-N6-)-methyltransferase specific for the capped 5′-end of messenger RNA. J. Biol. Chem. 253 (1978) 5033–5039. [PMID: 670176] 2.  Mauer, J., Luo, X., Blanjoie, A., Jiao, X., Grozhik, A.V., Patil, D.P., Linder, B., Pickering, B.F., Vasseur, J.J., Chen, Q., Gross, S.S., Elemento, O., Debart, F., Kiledjian, M. and Jaffrey, S.R. Reversible methylation of m6Am in the 5′ cap controls mRNA stability. Nature 541 (2017) 371–375. [PMID: 28002401]
[EC 2.1.1.62 created 1982]